Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.49 |
| ▸ | CETP | P11597 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934551 | 0.86 | GLS (0.61) | MAPK14ROCK1ROCK2GLSKDM5A | |
| SCHEMBL13853494 | 0.86 | MAPK14 (0.60) | MAPK14ROCK1ROCK2AKR1C3GLS | |
| SCHEMBL13647056 | 0.85 | MAPK14 (0.63) | MAPK14ROCK1ROCK2GLSKDM5A | |
| SCHEMBL14684325 | 0.85 | MAPK14 (0.59) | MAPK14ROCK1ROCK2AKR1C3GLS | |
| SCHEMBL23195276 | 0.84 | MAPK14 (0.65) | MAPK14ROCK1ROCK2AKR1C3GLS | |
| SCHEMBL30152446 | 0.84 | MAPK14 (0.65) | MAPK14ROCK1ROCK2AKR1C3GLS | |
| SCHEMBL18526150 | 0.83 | MAPK14 (0.58) | MAPK14ROCK1ROCK2AKR1C3GLS | |
| SCHEMBL3638883 | 0.83 | EPHX2 (0.58) | MAPK14ROCK1ROCK2GLSKCNB1 | |
| SCHEMBL4575965 | 0.83 | MAPK14 (0.60) | MAPK14ROCK1ROCK2GLSKDM5A | |
| SCHEMBL16477693 | 0.82 | MAPK14 (0.57) | MAPK14ROCK1ROCK2AKR1C3GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | claimed |
| US-11292801-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11292801-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN2, CAPN1 | MAPK14 2583/4885ROCK1 1766/4885ROCK2 1615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.