Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 4/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638883 | 0.89 | EPHX2 (0.58) | GLSMAPK14ROCK2ROCK1PTGER1 | |
| SCHEMBL934427 | 0.87 | EPHX2 (0.66) | GLSMAPK14ROCK2ROCK1EPHX2 | |
| SCHEMBL17335666 | 0.86 | EPHX2 (0.72) | MAPK14EPHX2 | |
| SCHEMBL5724446 | 0.86 | MAPK14 (0.63) | GLSMAPK14ROCK2ROCK1KCNB1 | |
| SCHEMBL14684325 | 0.85 | MAPK14 (0.59) | GLSMAPK14ROCK2ROCK1PTGER1 | |
| SCHEMBL22995143 | 0.84 | ALDH1A1 (0.55) | ROCK2ROCK1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL31036960 | 0.84 | ALDH1A1 (0.55) | ROCK2ROCK1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13853494 | 0.83 | MAPK14 (0.60) | GLSMAPK14ROCK2ROCK1KCNB1 | |
| SCHEMBL26051585 | 0.83 | MAPK14 (0.55) | GLSMAPK14ROCK2ROCK1PTGER1 | |
| SCHEMBL13647056 | 0.83 | MAPK14 (0.63) | GLSMAPK14ROCK2ROCK1KCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884814-B2 | Acylguanidines for treating osteoarthritis | MERCK PATENT GMBH (DE) | 2018-02-06 | — | — | US | disclosed |
| US-20150361037-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
| EP-2945929-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-11-25 | — | — | EP | disclosed |
| WO-2014111113-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-07-24 | — | — | WO | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361037-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | CTSG, CTSD, CTSB | GLS 406/4885MAPK14 1322/4885ROCK2 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.