SCHEMBL5724490

SCHEMBL5724490

CN(CCO[Si](C)(C)C(C)(C)C)C(=O)c1csc(N2CC(O)C2)n1

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
OGA O60502 2/20 0.35
GAA P10253 1/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
RXFP1 Q9HBX9 1/20 0.31
DGAT1 O75907 3/20 0.31
ALDH1A1 P00352 2/20 0.30
MEN1 O00255 1/20 0.30
LMNA P02545 1/20 0.30
POLB P06746 1/20 0.30
HPGD P15428 1/20 0.30
BLM P54132 1/20 0.30
KMT2A Q03164 1/20 0.30
ESR2 Q92731 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5723834 0.89 OGA (0.32) OGAL3MBTL1RXFP1
SCHEMBL5724508 0.88 OGA (0.33) OGA
SCHEMBL5724264 0.87 OGA (0.33) OGAL3MBTL1RXFP1
SCHEMBL5723757 0.81 OGA (0.37) OGAL3MBTL1RXFP1ALDH1A1MEN1
SCHEMBL5723999 0.80 OGA (0.35) OGAALDH1A1LMNAHPGDMAPT
SCHEMBL5724004 0.79 OGA (0.34) OGAGAAL3MBTL1RXFP1ALDH1A1
SCHEMBL5724491 0.79 OGA (0.33) OGA
SCHEMBL5723742 0.78 OGA (0.31) OGA
SCHEMBL5723823 0.77 OGA (0.36) OGAL3MBTL1RXFP1
SCHEMBL5725173 0.76 OGA (0.46) OGAL3MBTL1RXFP1ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1340757-B1 1-METHYLCARBAPENEM DERIVATIVES SANKYO CO (JP) 2006-10-11 EP disclosed
US-7001897-B2 1-methylcarbapenem derivatives SANKYO COMPANY, LIMITED (JP) 2006-02-21 US disclosed
US-20040014962-A1 1-Methylcarbapenem derivatives SANKYO COMPANY, LIMITED (JP) 2004-01-22 US disclosed
EP-1340757-A1 1-METHYLCARBAPENEM DERIVATIVES Sankyo Company, Limited (JP) 2003-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014962-A1 1-Methylcarbapenem derivatives CD14, CPT1A, ACMSD OGA 3469/4885GAA 2649/4885L3MBTL1 318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.