Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 11/20 | 0.51 |
| ▸ | PPARA | Q07869 | 11/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726538 | 0.90 | KDR (0.64) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL5724746 | 0.85 | PPARG (0.57) | KDRPPARGPPARA | |
| SCHEMBL5725488 | 0.83 | PPARG (0.62) | KDRPPARGPPARA | |
| SCHEMBL3527831 | 0.81 | KDR (0.69) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL5397217 | 0.81 | FFAR1 (0.57) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL6968514 | 0.80 | KDR (0.60) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL6968517 | 0.80 | KDR (0.60) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL6091207 | 0.79 | SMPD1 (0.50) | FFAR1PPARGMAPT | |
| SCHEMBL6089878 | 0.79 | CYSLTR2 (0.44) | PPARGMAPT | |
| SCHEMBL3528719 | 0.78 | KDR (0.76) | KDRFFAR1PPARGPPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177176-B1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA GMBH (DE) | 2006-04-19 | — | — | EP | disclosed |
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |