Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087956 | 0.88 | PTGER4 (0.55) | SMPD1PTGER4PTGER3F10NR4A2 | |
| SCHEMBL6088473 | 0.82 | HIF1A (0.57) | SMPD1KMT2ANR4A2MRGPRX4HIF1A | |
| SCHEMBL6092100 | 0.82 | RXRA (0.51) | PTGER4MEN1KMT2ANR4A2MRGPRX4 | |
| SCHEMBL6089878 | 0.82 | CYSLTR2 (0.44) | MAPTPPARGPTGER4JAK2JAK3 | |
| SCHEMBL6088897 | 0.81 | GABRA1 (0.52) | MAPTMEN1KMT2AFFAR1 | |
| SCHEMBL6088959 | 0.81 | MAOB (0.48) | SMPD1MAPTMEN1HSP90AA1KMT2A | |
| SCHEMBL4450809 | 0.80 | NR4A2 (0.58) | SMPD1PTGER4MEN1KMT2ANR4A2 | |
| SCHEMBL5724948 | 0.79 | KDR (0.59) | MAPTPPARGFFAR1 | |
| SCHEMBL6089484 | 0.77 | DPP4 (0.40) | MAPTFFAR1MAOB | |
| SCHEMBL6087974 | 0.77 | HIF1A (0.58) | SMPD1MAPTKMT2ANR4A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |