Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.62 |
| ▸ | PPARA | Q07869 | 18/20 | 0.62 |
| ▸ | PPARD | Q03181 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726538 | 0.93 | KDR (0.64) | PPARGPPARAKDR | |
| SCHEMBL5724746 | 0.92 | PPARG (0.57) | PPARGPPARAKDR | |
| SCHEMBL5724948 | 0.83 | KDR (0.59) | PPARGPPARAKDR | |
| SCHEMBL5580833 | 0.81 | PPARG (0.66) | PPARGPPARA | |
| SCHEMBL5761671 | 0.80 | PPARG (0.65) | PPARGPPARAKDR | |
| SCHEMBL7740069 | 0.79 | PPARG (0.69) | PPARGPPARAPPARD | |
| SCHEMBL13721507 | 0.79 | PPARG (0.65) | PPARGPPARA | |
| SCHEMBL4389208 | 0.79 | PPARG (0.79) | PPARGPPARAPPARD | |
| SCHEMBL6088674 | 0.79 | SLC26A4 (0.63) | — | |
| SCHEMBL5105473 | 0.79 | PPARA (0.82) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177176-B1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA GMBH (DE) | 2006-04-19 | — | — | EP | disclosed |
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |