SCHEMBL5725604

SCHEMBL5725604

CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc(N3CCN(C(=O)OCc4ccccc4)CC3)c(F)c2)C(=O)O1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.56
MAOA P21397 4/20 0.56
LMNA P02545 1/20 0.55
PTGS1 P23219 1/20 0.55
CALML3 P27482 1/20 0.55
SDHA P31040 1/20 0.55
F10 P00742 12/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5725608 1.00 MAOB (0.56) MAOBMAOALMNAPTGS1CALML3
SCHEMBL1498671 0.91 MAOB (0.67) MAOBMAOALMNAPTGS1CALML3
SCHEMBL5323788 0.91 MAOB (0.67) MAOBMAOALMNAPTGS1CALML3
SCHEMBL10151560 0.88 MAOB (0.54) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6229500 0.88 MAOB (0.56) MAOBMAOALMNAPTGS1CALML3
SCHEMBL10151452 0.87 MAOB (0.62) MAOBMAOALMNAPTGS1CALML3
SCHEMBL12665684 0.86 MAOB (0.56) MAOBMAOALMNAPTGS1CALML3
SCHEMBL5327254 0.85 MAOB (0.53) MAOBMAOALMNAPTGS1CALML3
SCHEMBL1498683 0.85 MAOB (0.53) MAOBMAOALMNAPTGS1CALML3
SCHEMBL4173980 0.85 MAOA (0.60) MAOBMAOALMNAPTGS1CALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1328509-B1 METHODS OF PRODUCING OXAZOLIDINONE COMPOUNDS PHARMACIA & UPJOHN CO LLC (US) 2006-03-22 EP disclosed
US-6998420-B2 Oxazolidinone compounds PHARMACIA & UPJOHN COMPANY (US) 2006-02-14 US disclosed
US-20040143131-A1 in particular,manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol, intermediates PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040143131-A1 in particular,manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol, intermediates TET1, NAT10, TET3 MAOB 3604/4885MAOA 3886/4885LMNA 2044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.