Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388588 | 0.83 | DHFR (0.59) | LMNAHSP90AB1HSP90AA1DHFRDPP4 | |
| SCHEMBL5726328 | 0.81 | HSP90AB1 (0.44) | LMNAHSP90AB1HSP90AA1DHFRDPP4 | |
| SCHEMBL5727729 | 0.80 | FGFR1 (0.41) | HSP90AB1HSP90AA1DHFRDPP4KDM4E | |
| SCHEMBL6049514 | 0.77 | KDM4E (0.52) | LMNAHSP90AB1HSP90AA1DHFRDPP4 | |
| SCHEMBL14237507 | 0.74 | HSP90AA1 (0.50) | LMNAHSP90AB1HSP90AA1DPP4KDM4E | |
| SCHEMBL6049482 | 0.74 | KCNK2 (0.57) | LMNADPP4KDM4ERAB9AALDH1A1 | |
| SCHEMBL6049452 | 0.73 | HSP90AB1 (0.50) | LMNAHSP90AB1HSP90AA1DHFRDPP4 | |
| SCHEMBL5070764 | 0.71 | KCNK2 (0.74) | POLB | |
| SCHEMBL4196232 | 0.70 | DHFR (0.61) | DHFRMAPT | |
| SCHEMBL29624840 | 0.70 | AHR (0.64) | HSP90AB1HSP90AA1KDM4ERAB9AMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395568-B1 | 4-AMINOPYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | claimed |