Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | HTR2C | P28335 | 5/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 10/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727854 | 0.93 | GHSR (0.52) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5726744 | 0.89 | DRD2 (0.57) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5727521 | 0.88 | DRD2 (0.58) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5727648 | 0.88 | DRD2 (0.57) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5727550 | 0.87 | DRD2 (0.71) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5727546 | 0.87 | GHSR (0.62) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5726850 | 0.86 | DRD2 (0.52) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5727922 | 0.85 | DRD2 (0.59) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5726999 | 0.80 | GHSR (0.55) | HTR6DRD2HTR2CDRD3HTR2A | |
| SCHEMBL5727204 | 0.79 | DRD2 (0.49) | HTR6DRD2HTR2CDRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549639-B1 | SULPHONAMIDE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LTD (GB) | 2006-05-24 | — | — | EP | claimed |