Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.74 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.74 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.57 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 4/20 | 0.50 |
| ▸ | CTSK | P43235 | 4/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728905 | 1.00 | ITGB3 (0.74) | ITGB3ITGA2BPTPN1ACEHDAC8 | |
| SCHEMBL14343053 | 0.90 | ITGB3 (0.70) | ITGB3ITGA2BPTPN1ACEHDAC8 | |
| SCHEMBL5892285 | 0.89 | ITGB3 (0.60) | ITGB3ITGA2BPTPN1HDAC8BCL2 | |
| SCHEMBL2728593 | 0.89 | ITGB3 (0.60) | ITGB3ITGA2BPTPN1HDAC8BCL2 | |
| SCHEMBL6685168 | 0.89 | ITGB3 (0.79) | ITGB3ITGA2BPTPN1ACEHDAC8 | |
| SCHEMBL6998950 | 0.89 | ITGB3 (0.79) | ITGB3ITGA2BPTPN1ACEHDAC8 | |
| SCHEMBL14937759 | 0.88 | ITGB3 (0.74) | ITGB3ITGA2BPTPN1ACEHDAC8 | |
| SCHEMBL27180793 | 0.88 | ITGB3 (0.74) | ITGB3ITGA2BPTPN1ACEHDAC8 | |
| SCHEMBL13367280 | 0.88 | ITGB3 (0.74) | ITGB3ITGA2BPTPN1ACEHDAC8 | |
| SCHEMBL16861093 | 0.88 | ITGB3 (0.74) | ITGB3ITGA2BPTPN1ACEHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1502590-B1 | Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type II diabetes | SERVIER LAB (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1502590-A1 | Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type II diabetes | Les Laboratoires Servier (FR) | 2005-02-02 | — | — | EP | disclosed |
| CN-1152338-A | Streptogramines and method for preparing same by mutasynthesis | RHONE POULENC RORER SA (FR) | 1997-06-18 | — | — | CN | disclosed |