Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 17/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 15/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 15/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 15/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10057885 | 0.85 | ACE (0.55) | KLK5ACE | |
| SCHEMBL572136 | 0.85 | ACE (0.55) | KLK5ACE | |
| SCHEMBL10056843 | 0.79 | ACE (0.48) | DPP4DPP8DPP9DPP7CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL572058 | 0.77 | DPP4 (0.47) | DPP4DPP8DPP9DPP7CYP2D6 | |
| SCHEMBL10057504 | 0.77 | ACE (0.51) | KLK5DPP4DPP8DPP9DPP7 | |
| SCHEMBL572693 | 0.73 | ACE (0.49) | KLK5DPP4DPP8ACEPREP | |
| SCHEMBL14982904 | 0.73 | ACE (0.49) | KLK5DPP4DPP8ACEPREP | |
| SCHEMBL6693358 | 0.72 | KLK5 (0.54) | KLK5DPP4ACEELANE | |
| SCHEMBL6693361 | 0.72 | KLK5 (0.54) | KLK5DPP4ACEELANE | |
| SCHEMBL14102471 | 0.71 | KLK5 (0.54) | KLK5DPP4DPP9ACEPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600888-A2 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | Cadila Pharmaceuticals Ltd. (IN) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017391-A2 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | CADILA PHARMACEUTICALS LIMITED (IN) | 2012-02-09 | — | — | WO | disclosed |