Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 1.00 |
| ▸ | AKT2 | P31751 | 1/20 | 0.79 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.79 |
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.75 |
| ▸ | JAK3 | P52333 | 1/20 | 0.74 |
| ▸ | CDK1 | P06493 | 1/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.74 |
| ▸ | NEK2 | P51955 | 1/20 | 0.74 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.69 |
| ▸ | FLT1 | P17948 | 3/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727586 | 1.00 | PDPK1 (1.00) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL29770021 | 0.88 | PDPK1 (1.00) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL5728134 | 0.88 | PDPK1 (1.00) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL5728132 | 0.88 | PDPK1 (1.00) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL5728368 | 0.85 | PDPK1 (0.74) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL5728365 | 0.85 | PDPK1 (0.74) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL5362145 | 0.85 | PDPK1 (0.81) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL5851557 | 0.84 | PDPK1 (0.84) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL5851570 | 0.84 | PDPK1 (0.84) | PDPK1AKT2PDK1TLK2JAK3 | |
| SCHEMBL13080513 | 0.84 | TLK2 (1.00) | PDPK1AKT2PDK1TLK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680401-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | Schering Aktiengesellschaft (DE) | 2006-07-19 | — | — | EP | claimed |
| WO-2005040116-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | claimed |
| US-20050090541-A1 | Indolinone derivatives and their use in treating disease-states such as cancer | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-04-28 | — | — | US | claimed |
| US-7105563-B2 | Indolinone derivatives and their use in treating disease-states such as cancer | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-09-12 | — | — | US | disclosed |
| EP-1680401-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | Schering Aktiengesellschaft (DE) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040116-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | disclosed |
| US-20050090541-A1 | Indolinone derivatives and their use in treating disease-states such as cancer | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090541-A1 | Indolinone derivatives and their use in treating disease-states such as cancer | PDK3, PDK2, PDK4 | PDPK1 4/4885AKT2 1359/4885PDK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.