Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 8/20 | 1.00 |
| ▸ | PDPK1 | O15530 | 7/20 | 0.80 |
| ▸ | JAK3 | P52333 | 4/20 | 0.80 |
| ▸ | CDK1 | P06493 | 1/20 | 0.73 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.73 |
| ▸ | NEK2 | P51955 | 1/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.70 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.69 |
| ▸ | FLT1 | P17948 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | PAK4 | O96013 | 1/20 | 0.67 |
| ▸ | AKT2 | P31751 | 1/20 | 0.66 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20944 | 0.89 | TLK2 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL20945 | 0.89 | TLK2 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL5728440 | 0.88 | PDPK1 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL5728434 | 0.88 | PDPK1 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL5361523 | 0.87 | PDPK1 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL5728671 | 0.87 | PDPK1 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL12200908 | 0.84 | NEK2 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL31061298 | 0.84 | NEK2 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL5727586 | 0.84 | PDPK1 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 | |
| SCHEMBL5727583 | 0.84 | PDPK1 (1.00) | TLK2PDPK1JAK3CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, HTT, PARK7 | TLK2 2365/4885PDPK1 438/4885JAK3 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.