Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728684 | 0.91 | SLC6A2 (0.38) | KDM4ECHEK1SLC6A2SLC6A4CHRM1 | |
| SCHEMBL5728123 | 0.88 | KDM4E (0.36) | KDM4EHTTATMCHEK1 | |
| SCHEMBL5433037 | 0.86 | CHEK1 (0.41) | KDM4EHTTATMCHEK1SLC6A2 | |
| SCHEMBL5433041 | 0.86 | CHEK1 (0.41) | KDM4EHTTATMCHEK1SLC6A2 | |
| SCHEMBL5438394 | 0.85 | ALDH1A1 (0.45) | KDM4EHTTATMCHEK1SLC6A2 | |
| SCHEMBL5438391 | 0.85 | ALDH1A1 (0.45) | KDM4EHTTATMCHEK1SLC6A2 | |
| SCHEMBL2871147 | 0.85 | KDM4E (0.36) | KDM4EHTTATMCHEK1SLC6A2 | |
| SCHEMBL5728035 | 0.85 | OPRM1 (0.35) | KDM4EHTTATMCHRM3 | |
| SCHEMBL5430676 | 0.84 | ALDH1A1 (0.48) | KDM4EHTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5430668 | 0.84 | ALDH1A1 (0.48) | KDM4EHTTSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |