Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 19/20 | 0.62 |
| ▸ | CDK9 | P50750 | 19/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | CDK4 | P11802 | 2/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.57 |
| ▸ | CCND1 | P24385 | 2/20 | 0.57 |
| ▸ | ABL2 | P42684 | 2/20 | 0.57 |
| ▸ | GSK3A | P49840 | 2/20 | 0.57 |
| ▸ | CDK7 | P50613 | 2/20 | 0.57 |
| ▸ | CCNH | P51946 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108860 | 0.86 | CYP1A2 (0.48) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4116169 | 0.86 | CYP1A2 (0.51) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4098423 | 0.83 | ALDH1A1 (0.68) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4101911 | 0.83 | USP2 (0.71) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4104588 | 0.81 | USP2 (0.79) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4104601 | 0.81 | USP2 (0.68) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4114595 | 0.81 | ALDH1A1 (0.71) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4097323 | 0.81 | USP2 (0.64) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL4098780 | 0.81 | USP2 (0.67) | USP2ALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL2997322 | 0.81 | CDK9 (0.81) | USP2ALDH1A1LMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678147-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC Biotech AG (DE) | 2006-07-12 | — | — | EP | claimed |
| WO-2005026129-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC BIOTECH AG (DE) | 2005-03-24 | — | — | WO | claimed |