Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.42 |
| ▸ | BRD4 | O60885 | 4/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL572885 | 0.90 | SPR (0.53) | SPRALKMAP3K7IRAK4MET | |
| SCHEMBL10270100 | 0.84 | ALK (0.52) | SPRALKMAP3K7IRAK4MET | |
| SCHEMBL572515 | 0.82 | ALK (0.44) | SPRALKBRD4CREBBPMAP3K7 | |
| SCHEMBL572514 | 0.82 | ALK (0.44) | SPRALKBRD4CREBBPMAP3K7 | |
| SCHEMBL572510 | 0.78 | SPR (0.59) | SPRALKBRD4CREBBPMAP3K7 | |
| SCHEMBL572476 | 0.76 | SPR (0.59) | SPRALKMET | |
| SCHEMBL15192746 | 0.76 | SPR (0.55) | SPRALKMAP3K7IRAK4MET | |
| SCHEMBL571730 | 0.75 | SPR (0.51) | SPRALKBRD4CREBBPMAP3K7 | |
| SCHEMBL10270391 | 0.73 | ALK (0.52) | SPRALKMAP3K7IRAK4MET | |
| SCHEMBL572239 | 0.72 | ALK (0.60) | SPRALKBRD4CREBBPMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611784-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | Amgen, Inc (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |