Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 1/20 | 0.52 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 9/20 | 0.45 |
| ▸ | PPARA | Q07869 | 9/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729613 | 0.92 | PPARA (0.53) | GSTP1GSTM2PPARGPPARAPPARD | |
| SCHEMBL5729755 | 0.92 | PPARA (0.53) | GSTP1GSTM2PPARGPPARAPPARD | |
| SCHEMBL5969493 | 0.92 | PPARA (0.53) | GSTP1GSTM2PPARGPPARAPPARD | |
| SCHEMBL28630326 | 0.86 | PPARA (0.51) | GSTP1GSTM2PPARGPPARAPPARD | |
| SCHEMBL20280001 | 0.86 | PPARA (0.51) | GSTP1GSTM2PPARGPPARAPPARD | |
| SCHEMBL5969038 | 0.86 | GSTP1 (0.52) | GSTP1GSTM2ALDH1A1MAPTNFKB1 | |
| SCHEMBL5729874 | 0.86 | GSTP1 (0.52) | GSTP1GSTM2ALDH1A1MAPTNFKB1 | |
| SCHEMBL5728927 | 0.86 | GSTP1 (0.52) | GSTP1GSTM2ALDH1A1MAPTNFKB1 | |
| SCHEMBL5969068 | 0.85 | GSTP1 (0.47) | GSTP1GSTM2PPARGPPARAPPARD | |
| SCHEMBL5728890 | 0.85 | GSTP1 (0.47) | GSTP1GSTM2PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434870-B1 | ENZYMATIC PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-AMINO-3-(2-AMINO-PHENYLSULFANYL)-PROPIONIC ACID | HOFFMANN LA ROCHE (CH) | 2006-12-27 | — | — | EP | disclosed |
| US-7011960-B2 | Substituted 2-amino-3-(2-amino-phenylsulfanyl)-propionic acids | HOFFMANN-LA ROCHE INC. (US) | 2006-03-14 | — | — | US | disclosed |
| EP-1434870-A1 | ENZYMATIC PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-AMINO-3-(2-AMINO-PHENYLSULFANYL)-PROPIONIC ACID | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-07 | — | — | EP | disclosed |
| US-20030119152-A1 | Substituted 2-amino-3- (2-amino-phenylsulfanyl) -propionic acids | HOFFMANN-LA ROCHE INC. | 2003-06-26 | — | — | US | disclosed |
| WO-2003029477-A1 | ENZYMATIC PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-AMINO-3-(2-AMINO-PHENYLSULFANYL)-PROPIONIC ACID | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119152-A1 | Substituted 2-amino-3- (2-amino-phenylsulfanyl) -propionic acids | CCKAR, AGTR1, AGTR2 | GSTP1 1257/4885GSTM2 2055/4885PPARG 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.