Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353021 | 0.98 | NPC1 (0.47) | NPC1RAB9AHPGDSMN1; SMN2HDAC3 | |
| SCHEMBL5730809 | 0.91 | NR1H4 (0.47) | NPC1RAB9AHPGDSMN1; SMN2HDAC3 | |
| SCHEMBL5730023 | 0.91 | HPGD (0.50) | NPC1RAB9AHPGDSMN1; SMN2NR1H4 | |
| SCHEMBL5730910 | 0.89 | NR1H4 (0.45) | NPC1RAB9AHPGDSMN1; SMN2HDAC1 | |
| SCHEMBL5731178 | 0.87 | HPGD (0.51) | NPC1RAB9AHPGDSMN1; SMN2NR1H4 | |
| SCHEMBL5729685 | 0.81 | NQO2 (0.47) | NPC1RAB9AHPGDSMN1; SMN2EPHX2 | |
| SCHEMBL5729898 | 0.73 | PPARA (0.42) | NPC1RAB9AHPGDLMNA | |
| SCHEMBL4896559 | 0.71 | PPARG (0.52) | NPC1RAB9AHPGDSMN1; SMN2HDAC3 | |
| SCHEMBL5730663 | 0.70 | NPC1 (0.52) | NPC1RAB9AHPGDSMN1; SMN2EPHX2 | |
| SCHEMBL7324247 | 0.69 | MAPT (0.63) | NPC1RAB9AHPGDSMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401434-B1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | LILLY CO ELI (US) | 2006-11-15 | — | — | EP | disclosed |