Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731178 | 0.84 | HPGD (0.51) | EPHX2MMP13HPGDNPC1RAB9A | |
| SCHEMBL5730809 | 0.81 | NR1H4 (0.47) | EPHX2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5730910 | 0.81 | NR1H4 (0.45) | EPHX2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5730050 | 0.81 | HPGD (0.50) | EPHX2MMP13HPGDNPC1RAB9A | |
| SCHEMBL5730023 | 0.81 | HPGD (0.50) | EPHX2MMP13HPGDNPC1RAB9A | |
| SCHEMBL5730552 | 0.81 | NPC1 (0.47) | EPHX2HPGDNPC1RAB9AMEN1 | |
| SCHEMBL5353021 | 0.81 | NPC1 (0.47) | EPHX2MMP13HPGDNPC1RAB9A | |
| SCHEMBL5355635 | 0.78 | MAPT (0.52) | HPGDALDH1A1 | |
| SCHEMBL4896578 | 0.75 | EPHX2 (0.54) | NQO2MTNR1AMTNR1BHPGDSEPHX2 | |
| SCHEMBL7134254 | 0.69 | MMP13 (0.86) | MMP13HPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401434-B1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | LILLY CO ELI (US) | 2006-11-15 | — | — | EP | disclosed |
| EP-1401434-A1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | ELI LILLY AND COMPANY (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100403-A1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | ELI LILLY AND COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |