Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 5/20 | 0.38 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2614860 | 0.90 | HTR2C (0.44) | HTR2CKMT2AATMPRKCIKHK | |
| SCHEMBL1321222 | 0.88 | HTR2C (0.43) | HTR2CKMT2AATMPRKCIKHK | |
| SCHEMBL1320860 | 0.88 | HTR2C (0.43) | HTR2CKMT2AATMPRKCIKHK | |
| SCHEMBL1321171 | 0.86 | HTR2C (0.42) | HTR2CKMT2AATMPRKCIKHK | |
| SCHEMBL5730454 | 0.86 | PRKCI (0.46) | HTR2CKMT2AATMPRKCIKHK | |
| SCHEMBL1321736 | 0.84 | PRKCI (0.43) | HTR2CKMT2AATMPRKCIKHK | |
| Hydrochloric Acid SCHEMBL5731014 | 0.83 | PRKCI (0.42) | HTR2CKMT2AATMPRKCIKHK | |
| SCHEMBL1322258 | 0.82 | PRKCI (0.43) | HTR2CKMT2AATMPRKCIKHK | |
| SCHEMBL5730893 | 0.82 | HRH3 (0.39) | KMT2APRKCIHRH3TRIM58KDM4E | |
| SCHEMBL1322483 | 0.81 | KMT2A (0.42) | HTR2CKMT2AATMPRKCIKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |