Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321338 | 0.89 | PRKCI (0.51) | PRKCIKDM4EALDH1A1KMT2AHTR2C | |
| SCHEMBL5730721 | 0.89 | PRKCI (0.56) | PRKCIKDM4EKMT2AHTR2CPRKCZ | |
| SCHEMBL1320517 | 0.86 | PRKCI (0.49) | PRKCIKDM4EALDH1A1POLBGAA | |
| SCHEMBL5732076 | 0.85 | PRKCI (0.58) | PRKCIKDM4EHTR2CPRKCZCHRM4 | |
| SCHEMBL2614862 | 0.81 | PRKCI (0.54) | PRKCIKDM4EKMT2AHTR2CPRKCZ | |
| SCHEMBL5731354 | 0.81 | PRKCI (0.69) | PRKCIKDM4EKMT2AHTR2CNPSR1 | |
| SCHEMBL1321633 | 0.79 | ALDH1A1 (0.48) | PRKCIKDM4EALDH1A1POLBGAA | |
| SCHEMBL5731659 | 0.79 | HTR2C (0.62) | PRKCIKMT2AHTR2CPRKCZMAPT | |
| Hydrochloric Acid SCHEMBL1320514 | 0.78 | ALDH1A1 (0.47) | PRKCIKDM4EALDH1A1POLBGAA | |
| SCHEMBL1321699 | 0.77 | PRKCI (0.52) | PRKCIKDM4EALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |