Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 11/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730721 | 0.96 | PRKCI (0.56) | PRKCIHTR2CCHRM4KDM4EMAPT | |
| SCHEMBL5731659 | 0.86 | HTR2C (0.62) | PRKCIHTR2CMAPTPRKCZ | |
| SCHEMBL5731146 | 0.85 | PRKCI (0.52) | PRKCIHTR2CCHRM4KDM4EMAPT | |
| SCHEMBL5731616 | 0.85 | PRKCI (0.54) | PRKCICHRM4KDM4EMAPTPRKCZ | |
| SCHEMBL2614868 | 0.83 | PRKCI (0.54) | PRKCIHTR2CCHRM4KDM4EMAPT | |
| SCHEMBL2614862 | 0.83 | PRKCI (0.54) | PRKCIHTR2CCHRM4KDM4EMAPT | |
| SCHEMBL1321338 | 0.82 | PRKCI (0.51) | PRKCIHTR2CCHRM4KDM4EPRKCZ | |
| SCHEMBL1321733 | 0.81 | PRKCI (0.52) | PRKCIHTR2CCHRM4KDM4EMAPT | |
| SCHEMBL5731354 | 0.81 | PRKCI (0.69) | PRKCIHTR2CCHRM4KDM4EMAPT | |
| SCHEMBL5731318 | 0.81 | HTR2C (0.60) | PRKCIHTR2CCHRM4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |