Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | GLA | P06280 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PDE8B | O95263 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.43 |
| ▸ | PNP | P00491 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731691 | 0.87 | TLR7 (0.43) | KDM4EALDH1A1HPGDHSD17B10TLR7 | |
| SCHEMBL5730974 | 0.87 | TLR7 (0.43) | KDM4EALDH1A1GAAHPGDNPSR1 | |
| SCHEMBL5731373 | 0.86 | TLR7 (0.42) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL5730944 | 0.84 | TLR7 (0.55) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL5731860 | 0.83 | TLR7 (0.43) | KMT2ATLR7 | |
| SCHEMBL5731748 | 0.82 | CCR9 (0.42) | KMT2ATLR7SMN1; SMN2TP53 | |
| SCHEMBL10309737 | 0.81 | TLR7 (0.44) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL5731246 | 0.81 | FBP1 (0.44) | ALDH1A1KMT2ATLR7SMN1; SMN2 | |
| SCHEMBL10309731 | 0.80 | KDM4E (0.39) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL5731513 | 0.80 | L3MBTL1 (0.50) | KDM4ENPSR1MAPK1KMT2ATLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043021-B1 | PURINE DERIVATIVES FOR THE TREATMENT OF ALLERGIC DISEASES AND SYSTEMIC LUPUS ERYTHEMATOSUS | DAINIPPON SUMITOMO PHARMA CO (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-0882727-B9 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0882727-B1 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6376501-B1 | INHIBITING OR REGULATING IMMUNE RESPONSE USING PURINE-DERIVED COMPOUND; NON-STEROIDAL COMPOUND | JAPAN ENERGY CORPORATION (JP) | 2002-04-23 | — | — | US | disclosed |
| EP-1043021-A1 | TYPE 2 HELPER T CELL-SELECTIVE IMMUNE RESPONSE SUPPRESSORS | Japan Energy Corporation (JP) | 2000-10-11 | — | — | EP | disclosed |
| US-6028076-A | FOR INDUCING .ALPHA.-INTERFERON IN A PATIENT HAVING HEPATITIS B OR C, BY ADMINISTERING PURINE DERIVATIVE | JAPAN ENERGY CORPORATION (JP) | 2000-02-22 | — | — | US | disclosed |
| EP-0882727-A1 | NOVEL PURINE DERIVATIVES | JAPAN ENERGY CORPORATION (JP) | 1998-12-09 | — | — | EP | disclosed |