Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859632 | 0.86 | PLG (0.45) | SLC6A3DRD2SLC6A4TAAR1SIGMAR1 | |
| SCHEMBL13738991 | 0.76 | NOS1 (0.49) | SLC6A3MAOAMAOBDRD2SLC6A4 | |
| SCHEMBL15667906 | 0.76 | NOS1 (0.49) | SLC6A3MAOAMAOBDRD2SLC6A4 | |
| SCHEMBL13738989 | 0.76 | NOS1 (0.49) | SLC6A3MAOAMAOBDRD2SLC6A4 | |
| SCHEMBL5558065 | 0.75 | TAAR1 (0.44) | SLC6A3MAOAMAOBSLC6A4TAAR1 | |
| SCHEMBL5557203 | 0.75 | TAAR1 (0.44) | SLC6A3MAOAMAOBSLC6A4TAAR1 | |
| SCHEMBL20317594 | 0.75 | SLC6A3 (0.58) | SLC6A3DRD2SLC6A4TAAR1SIGMAR1 | |
| SCHEMBL13859660 | 0.72 | PLG (0.40) | — | |
| SCHEMBL13859666 | 0.71 | POLB (0.43) | — | |
| SCHEMBL11386097 | 0.71 | POLB (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664063-A1 | SUBSTITUTED PIPERAZINES OF AZEPINES, OXAZEPINES, AND THIAZEPINES | ELI LILLY AND COMPANY (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026177-A1 | SUBSTITUTED PIPERAZINES OF AZEPINES, OXAZEPINES, AND THIAZEPINES | ELI LILLY AND COMPANY (US) | 2005-03-24 | — | — | WO | disclosed |