Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5633107 | 1.00 | HTR2C (0.42) | HTR2CHTR2AHTR2BMAPTMEN1 | |
| SCHEMBL5632208 | 0.92 | HTR2C (0.45) | HTR2CHTR2AHTR2BMAPTMEN1 | |
| SCHEMBL5632634 | 0.92 | HTR2C (0.45) | HTR2CHTR2AHTR2BMAPTMEN1 | |
| SCHEMBL5632202 | 0.92 | HTR2C (0.45) | HTR2CHTR2AHTR2BMAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL5630462 | 0.85 | ALDH1A1 (0.37) | HTR2CHTR2AHTR2BALDH1A1GAA | |
| Trifluoroacetic Acid SCHEMBL5732644 | 0.85 | ALDH1A1 (0.37) | HTR2CHTR2AHTR2BALDH1A1GAA | |
| Trifluoroacetic Acid SCHEMBL5632699 | 0.85 | HTR2A (0.38) | HTR2CHTR2AHTR2BMAPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL27649809 | 0.85 | HTR2A (0.38) | HTR2CHTR2AHTR2BMAPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5632499 | 0.85 | KDM1A (0.36) | HTR2CHTR2AHTR2BHTR6BACE1 | |
| Trifluoroacetic Acid SCHEMBL5632354 | 0.85 | KDM1A (0.36) | HTR2CHTR2AHTR2BHTR6BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809545-A | N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5HT2c | ARENA PHARM INC (US) | 2006-07-26 | — | — | CN | disclosed |
| EP-1644347-A1 | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT sb 2C /sb RECEPTOR ASSOCIATED DISEASES | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005016902-A1 | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES | ARENA PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |