Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5630462 | 1.00 | ALDH1A1 (0.37) | ALDH1A1POLBGAATHRBHTR2C | |
| SCHEMBL5631361 | 0.93 | HTR2C (0.37) | ALDH1A1POLBGAATHRBHTR2C | |
| SCHEMBL5634074 | 0.93 | HTR2C (0.37) | ALDH1A1POLBGAATHRBHTR2C | |
| SCHEMBL5631356 | 0.93 | HTR2C (0.37) | ALDH1A1POLBGAATHRBHTR2C | |
| Trifluoroacetic Acid SCHEMBL5732284 | 0.85 | HTR2C (0.42) | ALDH1A1GAAHTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL5633107 | 0.85 | HTR2C (0.42) | ALDH1A1GAAHTR2CHTR2BHTR2A | |
| SCHEMBL5631132 | 0.85 | HTR2C (0.35) | HTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL27649809 | 0.82 | HTR2A (0.38) | ALDH1A1GAAHTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL5632699 | 0.82 | HTR2A (0.38) | ALDH1A1GAAHTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL5632499 | 0.82 | KDM1A (0.36) | HTR2CHTR2BHTR2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809545-A | N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5HT2c | ARENA PHARM INC (US) | 2006-07-26 | — | — | CN | disclosed |
| EP-1644347-A1 | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT sb 2C /sb RECEPTOR ASSOCIATED DISEASES | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005016902-A1 | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES | ARENA PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |