Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318705 | 1.00 | HTT (0.50) | HTTGAASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3320689 | 0.88 | HTT (0.52) | HTTGAASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL5731641 | 0.88 | HTT (0.52) | HTTGAASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3323347 | 0.87 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL5731482 | 0.87 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3318208 | 0.86 | HTT (0.48) | HTTGAASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL5731644 | 0.74 | HTT (0.42) | HTTGAASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3319710 | 0.74 | RAB9A (0.49) | HTTSMN1; SMN2ALDH1A1PKMMAPK1 | |
| SCHEMBL5732991 | 0.74 | RAB9A (0.49) | HTTSMN1; SMN2ALDH1A1PKMMAPK1 | |
| SCHEMBL3318983 | 0.73 | HTT (0.39) | HTTALDH1A1MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | disclosed |