Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374216 | 0.89 | GAA (0.46) | GAAGRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5374221 | 0.89 | GAA (0.46) | GAAGRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5203581 | 0.84 | GAA (0.54) | GAAGRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5374691 | 0.76 | GAA (0.47) | GAAGRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5733310 | 0.76 | GAA (0.44) | GAAGRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5733660 | 0.76 | GAA (0.54) | GAAGRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5732645 | 0.74 | F2 (0.50) | GAAOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5376256 | 0.73 | GAA (0.42) | GAAGRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7076356 | 0.73 | MMP2 (0.39) | SLC6A2SLC6A4SLC6A3OPRM1OPRD1 | |
| SCHEMBL7076354 | 0.73 | MMP2 (0.39) | SLC6A2SLC6A4SLC6A3OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |