Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374213 | 0.88 | F2 (0.50) | F2GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL5203573 | 0.83 | F2 (0.57) | F2GAAACHETNKSPARP1 | |
| SCHEMBL5374688 | 0.76 | GAA (0.47) | F2GAAACHEHDAC6 | |
| SCHEMBL5733306 | 0.75 | ROCK2 (0.51) | F2GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL5733657 | 0.75 | GAA (0.55) | F2GAAACHETNKSPARP1 | |
| SCHEMBL5732647 | 0.74 | GAA (0.48) | GAAOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL7076353 | 0.73 | PARP14 (0.39) | F2OPRM1OPRD1PARP14 | |
| SCHEMBL5734925 | 0.72 | F2 (0.47) | F2GAAACHE | |
| SCHEMBL5733400 | 0.71 | ROCK2 (0.41) | F2GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL5371447 | 0.69 | HDAC6 (0.55) | F2GAAACHETNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |