Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3178763 | 0.83 | KMT2A (0.68) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| SCHEMBL3178319 | 0.82 | KMT2A (0.68) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| SCHEMBL5732043 | 0.81 | KMT2A (0.67) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| SCHEMBL2493368 | 0.81 | KMT2A (0.67) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| SCHEMBL5731047 | 0.81 | KMT2A (0.67) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| SCHEMBL5731969 | 0.81 | KMT2A (0.67) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| Hydrochloric Acid SCHEMBL2493369 | 0.80 | KMT2A (0.69) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| Bromide SCHEMBL3176423 | 0.80 | KMT2A (0.65) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| SCHEMBL5732756 | 0.80 | KMT2A (0.64) | KMT2ALMNACYP2D6CYP1A2HIF1A | |
| SCHEMBL3163430 | 0.77 | MAPT (0.65) | KMT2ALMNACYP2D6CYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066486-A1 | REL INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066486-A1 | REL INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-03-06 | — | — | US | disclosed |
| US-20110118325-A1 | REL INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2011-05-19 | — | — | US | disclosed |
| EP-1651613-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | Aventis Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014555-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118325-A1 | REL INHIBITORS AND METHODS OF USE THEREOF | REL, RCOR3, RBBP4 | KMT2A 778/4885LMNA 1720/4885CYP2D6 4098/4885 |
| US-20140066486-A1 | REL INHIBITORS AND METHODS OF USE THEREOF | REL, RCOR3, RBBP4 | KMT2A 778/4885LMNA 1720/4885CYP2D6 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.