Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 13/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 11/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4105937 | 0.92 | CDK9 (0.53) | CDK9CCNT1EGFRERBB3CYP1A2 | |
| SCHEMBL4759000 | 0.89 | CDK9 (0.70) | CDK9CCNT1EGFRERBB3CYP1A2 | |
| SCHEMBL5760705 | 0.88 | EGFR (0.64) | CDK9CCNT1EGFRERBB3CYP1A2 | |
| SCHEMBL4103605 | 0.86 | CYP1A2 (0.55) | CDK9CCNT1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4116315 | 0.86 | CDK9 (0.69) | CDK9CCNT1EGFRERBB3CYP1A2 | |
| SCHEMBL5732695 | 0.84 | CDK9 (0.61) | CDK9CCNT1EGFRERBB3CYP1A2 | |
| SCHEMBL4098766 | 0.84 | CDK9 (0.63) | CDK9CCNT1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4761482 | 0.84 | CDK9 (0.59) | CDK9CCNT1EGFRERBB3CYP1A2 | |
| SCHEMBL4103945 | 0.82 | CDK9 (0.66) | CDK9CCNT1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4097394 | 0.82 | CDK9 (0.66) | CDK9CCNT1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678147-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC Biotech AG (DE) | 2006-07-12 | — | — | EP | claimed |
| WO-2005026129-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC BIOTECH AG (DE) | 2005-03-24 | — | — | WO | claimed |