Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.64 |
| ▸ | CDK9 | P50750 | 14/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 13/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4103963 | 0.92 | EGFR (0.54) | EGFRERBB3CDK9CCNT1MEN1 | |
| SCHEMBL4759000 | 0.89 | CDK9 (0.70) | EGFRERBB3CDK9CCNT1USP2 | |
| SCHEMBL5732695 | 0.89 | CDK9 (0.61) | EGFRERBB3CDK9CCNT1USP2 | |
| SCHEMBL5733331 | 0.88 | CDK9 (0.56) | EGFRERBB3CDK9CCNT1USP2 | |
| SCHEMBL4116315 | 0.86 | CDK9 (0.69) | EGFRERBB3CDK9CCNT1USP2 | |
| SCHEMBL4761482 | 0.84 | CDK9 (0.59) | EGFRERBB3CDK9CCNT1MEN1 | |
| SCHEMBL1243712 | 0.82 | CDK9 (0.56) | EGFRERBB3CDK9CCNT1MEN1 | |
| SCHEMBL4103945 | 0.82 | CDK9 (0.66) | CDK9CCNT1USP2ALDH1A1LMNA | |
| SCHEMBL4097394 | 0.82 | CDK9 (0.66) | CDK9CCNT1USP2ALDH1A1LMNA | |
| SCHEMBL5734993 | 0.82 | EGFR (0.68) | EGFRERBB3CDK9CCNT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678147-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC Biotech AG (DE) | 2006-07-12 | — | — | EP | claimed |
| WO-2005026129-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC BIOTECH AG (DE) | 2005-03-24 | — | — | WO | claimed |