Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203573 | 0.91 | F2 (0.57) | GAAF2ACHETNKSPARP1 | |
| SCHEMBL5374204 | 0.82 | CYP2C9 (0.47) | GAAF2MEN1KMT2A | |
| SCHEMBL5374688 | 0.81 | GAA (0.47) | GAAF2ACHE | |
| SCHEMBL5733306 | 0.80 | ROCK2 (0.51) | GAAF2ACHETNKSPARP1 | |
| SCHEMBL5201672 | 0.79 | MEN1 (0.57) | F2ACHEMEN1KMT2A | |
| SCHEMBL5372863 | 0.78 | F2 (0.59) | GAAF2TNKSPARP1PARP14 | |
| SCHEMBL5734925 | 0.77 | F2 (0.47) | GAAF2ACHE | |
| SCHEMBL7376188 | 0.76 | GAA (0.53) | GAAF2ACHETNKSPARP1 | |
| SCHEMBL5377979 | 0.76 | GAA (0.47) | GAAF2ACHETNKSPARP1 | |
| SCHEMBL5732645 | 0.75 | F2 (0.50) | GAAF2ACHETNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |