Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1004629 | 0.94 | CA4 (0.46) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL14243920 | 0.89 | CA4 (0.42) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL30978805 | 0.89 | — | — | |
| Bicarbonate SCHEMBL3737066 | 0.89 | CA4 (0.42) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL3742203 | 0.89 | CA4 (0.42) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL23322011 | 0.89 | — | — | |
| Bicarbonate SCHEMBL7111306 | 0.89 | CA4 (0.42) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL1515963 | 0.89 | CA4 (0.42) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL43479 | 0.88 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL9795399 | 0.88 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626697-A2 | PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION COMPRISING LITHIUM CARBONATE | GLAXO GROUP LIMITED (GB) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004105691-A2 | PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION COMPRISING LITHIUM CARBONATE | GLAXO GROUP LIMITED (GB) | 2004-12-09 | — | — | WO | disclosed |
| US-20040241252-A1 | Pharmaceutical compositions for oral administration comprising lithium carbonate, processes of making the same, and methods of administering the same | GLAXO GROUP LIMITED (GB) | 2004-12-02 | — | — | US | disclosed |