Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.65 |
| ▸ | MC4R | P32245 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729863 | 1.00 | SLC6A2 (0.65) | SLC6A2SLC6A4MC4RHTR7P2RX7 | |
| SCHEMBL4077041 | 0.80 | SLC6A2 (0.66) | SLC6A2SLC6A4 | |
| SCHEMBL4083723 | 0.80 | SLC6A2 (0.66) | SLC6A2SLC6A4 | |
| SCHEMBL28765777 | 0.80 | SLC6A2 (0.71) | SLC6A2SLC6A4 | |
| SCHEMBL6047909 | 0.79 | SLC6A2 (1.00) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL4083841 | 0.79 | SLC6A2 (0.64) | SLC6A2SLC6A4 | |
| SCHEMBL27668131 | 0.77 | SLC6A2 (0.67) | SLC6A2SLC6A4 | |
| SCHEMBL29519698 | 0.74 | SLC6A2 (0.62) | SLC6A2SLC6A4 | |
| SCHEMBL27687227 | 0.70 | SLC6A2 (0.58) | SLC6A2SLC6A4P2RX7 | |
| SCHEMBL8689275 | 0.68 | DRD2 (0.46) | SLC6A2SLC6A4MC4RP2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732887-A1 | 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005097744-A1 | 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2005-10-20 | — | — | WO | disclosed |