SCHEMBL5733754

SCHEMBL5733754

CCCC[Sn](CCCC)(CCCC)c1cnc(CN(C)C(=O)OCc2ccccc2)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
CYP3A4 P08684 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HDAC1 Q13547 1/20 0.35
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34
MCHR1 Q99705 1/20 0.33
F13A1 P00488 1/20 0.33
TGM2 P21980 1/20 0.33
TGM1 P22735 1/20 0.33
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
ATM Q13315 1/20 0.32
PTGES O14684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5733475 0.79 NPC1 (0.41) ALDH1A1HDAC1CHRNB2CHRNB4CHRNA3
SCHEMBL20794169 0.69 ALDH1A1 (0.52) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL13687204 0.69 CHRNB2 (0.61) ALDH1A1MAPK1TDP1L3MBTL1CHRNB2
SCHEMBL12013715 0.68 ALDH1A1 (0.51) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL5733926 0.68 POLB (0.51) ALDH1A1TSHRKMT2AMEN1ATM
SCHEMBL34465759 0.67 CHRNB2 (0.47) ALDH1A1HDAC1CHRNB2CHRNB4CHRNA3
SCHEMBL2724661 0.67 ALDH1A1 (0.53) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL9190944 0.66 ALDH1A1 (0.59) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL10107202 0.66 ALDH1A1 (0.56) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL29498709 0.66 PDGFRB (0.40) MAPK1CHRNB2CHRNB4CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070713-B1 QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF TOYAMA CHEMICAL CO LTD (JP) 2006-10-18 EP disclosed
US-6335447-B1 BACTERICIDES TOYAMA CHEMICAL CO., LTD. (JP) 2002-01-01 US disclosed
EP-1070713-A1 QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2001-01-24 EP disclosed