SCHEMBL573377

SCHEMBL573377

O=C(/C=C\C(=O)OCCc1ccccc1)OCCc1ccccc1

nearest known ligand 0.89

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.89
AKR1B10 O60218 6/20 0.77
AKR1B1 P15121 6/20 0.77
MAOB P27338 1/20 0.69
ALOX5 P09917 4/20 0.63
TTR P02766 4/20 0.63
CYP3A4 P08684 2/20 0.63
ALOX15 P16050 2/20 0.63
ALOX12 P18054 2/20 0.63
MAPK1 P28482 2/20 0.63
HSD17B10 Q99714 2/20 0.63
KDM4E B2RXH2 1/20 0.63
MEN1 O00255 1/20 0.63
GMNN O75496 1/20 0.63
ALDH1A1 P00352 1/20 0.63
EGFR P00533 1/20 0.63
LMNA P02545 1/20 0.63
ESR1 P03372 1/20 0.63
ERBB2 P04626 1/20 0.63
APP P05067 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3482701 1.00 HCAR2 (0.89) HCAR2AKR1B10AKR1B1MAOBALOX5
SCHEMBL9860306 1.00 HCAR2 (0.89) HCAR2AKR1B10AKR1B1MAOBALOX5
Phenylethyl Fumarate SCHEMBL573376 0.94 HCAR2 (1.00) HCAR2AKR1B10AKR1B1MAOBALOX5
Phenylethyl Fumarate SCHEMBL27750209 0.94 HCAR2 (1.00) HCAR2AKR1B10AKR1B1MAOBALOX5
Phenylethyl Fumarate SCHEMBL573379 0.94 HCAR2 (1.00) HCAR2AKR1B10AKR1B1MAOBALOX5
SCHEMBL25623741 0.91 HCAR2 (0.76) HCAR2AKR1B10AKR1B1MAOBALOX5
SCHEMBL27735855 0.91 HCAR2 (0.76) HCAR2AKR1B10AKR1B1MAOBALOX5
SCHEMBL7268059 0.91 HCAR2 (0.76) HCAR2AKR1B10AKR1B1MAOBALOX5
SCHEMBL23343675 0.91 HCAR2 (0.75) HCAR2AKR1B10AKR1B1MAOBALOX5
SCHEMBL29839413 0.90 HCAR2 (0.73) HCAR2AKR1B10AKR1B1MAOBALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9040630-B2 Graft copolymers of polyfarnesenes with condensation polymers Amyris, Inc. (US) 2015-05-26 US claimed
EP-2601229-B1 GRAFT COPOLYMERS OF POLYFARNESENES WITH CONDENSATION POLYMERS AMYRIS INC (US) 2013-10-16 EP claimed
EP-2601229-A1 GRAFT COPOLYMERS OF POLYFARNESENES WITH CONDENSATION POLYMERS Amyris, Inc. (US) 2013-06-12 EP claimed
US-20130123379-A1 GRAFT COPOLYMERS OF POLYFARNESENES WITH CONDENSATION POLYMERS Amyris, Inc. (US) 2013-05-16 US claimed
WO-2012018682-A1 GRAFT COPOLYMERS OF POLYFARNESENES WITH CONDENSATION POLYMERS Amyris, Inc. (US) 2012-02-09 WO claimed
EP-2817342-B1 POLYMERIZATION OF COMPOSITIONS COMPRISING A FARNESENE AMYRIS INC (US) 2016-05-25 EP disclosed
US-9040630-B2 Graft copolymers of polyfarnesenes with condensation polymers Amyris, Inc. (US) 2015-05-26 US disclosed
US-20150025193-A1 POLYMERIZATION OF COMPOSITIONS COMPRISING A FARNESENE Amyris, Inc. (US) 2015-01-22 US disclosed
EP-2817342-A1 POLYMERIZATION OF COMPOSITIONS COMPRISING A FARNESENE Amyris, Inc. (US) 2014-12-31 EP disclosed
US-8592543-B2 Polyfarnesenes EUAGORE, LLC 2013-11-26 US disclosed
CN-101267815-B metallo-beta-lactamase inhibitors MEIJI SEIKA PHARMA CO LTD 2013-11-06 CN disclosed
EP-2601229-B1 GRAFT COPOLYMERS OF POLYFARNESENES WITH CONDENSATION POLYMERS AMYRIS INC (US) 2013-10-16 EP disclosed
US-5362819-A Polyester-flexible polymer block copolymers and mixtures thereof GENCORP INC. (US) 1994-11-08 US disclosed
EP-0612786-A1 Polyester-flexible polymer block copolymers and mixtures thereof GENCORP INC. (US) 1994-08-31 EP disclosed
EP-0612787-A1 Polyester-flexible polymer block copolymer coated fiber structures and utilization thereof in a polymer matrix GENCORP INC. (US) 1994-08-31 EP disclosed
US-5334441-A Tough, noncracking, flexible sheet molding materials, for automobile panels, aircraft, housings GENCORP INC. (US) 1994-08-02 US disclosed
US-4654401-A SOLVENT RESISTANCE, HIGH IMPACT STRENGTH MOLDING MATERIAL GENERAL ELECTRIC COMPANY (US) 1987-03-31 US disclosed
US-4632962-A USING IN MAKING MODIFIED POLYESTERS, POLYCARBONATES GENERAL ELECTRIC COMPANY (US) 1986-12-30 US disclosed
EP-0186060-A2 Hydroxyl group graft modified polyolefins GENERAL ELECTRIC COMPANY (US) 1986-07-02 EP disclosed
US-4147740-A UNSATURATED ANHYDRIDE, HIGH IMPACT BLENDS GENERAL ELECTRIC COMPANY (US) 1979-04-03 US disclosed