Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432130 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL5732981 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL7440042 | 0.99 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL7432117 | 0.99 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL26370885 | 0.96 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL10145104 | 0.92 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL15692785 | 0.86 | MAPT (0.47) | ALDH1A1KMT2AMEN1MAPTNPC1 | |
| SCHEMBL16577350 | 0.86 | NPC1 (0.47) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL18871030 | 0.86 | MAPT (0.47) | ALDH1A1KMT2AMEN1MAPTNPC1 | |
| SCHEMBL18213981 | 0.83 | GSK3B (0.43) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973518-B1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | UNIV ILLINOIS (US) | 2006-03-29 | — | — | EP | disclosed |
| US-6841530-B2 | Semi-synthetic studies toward didemnin analogues | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2005-01-11 | — | — | US | disclosed |
| EP-0973518-A4 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | UNIV ILLINOIS (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20020037835-A1 | Semi-synthetic studies toward didemnin analogues | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE | 2002-03-28 | — | — | US | disclosed |
| US-20010007855-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE | 2001-07-12 | — | — | US | disclosed |
| EP-0973518-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998017275-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1998-04-30 | — | — | WO | disclosed |
| EP-0367514-A2 | Human leukocyte elastase inhibitors and methods for producing and using same | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-05-09 | — | — | EP | disclosed |
| WO-1990004409-A1 | HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007855-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | FAR1, FASN, GOT1 | ALDH1A1 1287/4885KMT2A 1281/4885MEN1 35/4885 |
| US-20020037835-A1 | Semi-synthetic studies toward didemnin analogues | FAR1, FASN, GOT1 | ALDH1A1 1287/4885KMT2A 1281/4885MEN1 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.