Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733894 | 0.92 | UTS2R (0.66) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5733669 | 0.92 | UTS2R (0.61) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5733792 | 0.90 | UTS2R (0.62) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5734152 | 0.90 | UTS2R (0.59) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5734458 | 0.90 | UTS2R (0.59) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5735683 | 0.89 | UTS2R (0.58) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5956412 | 0.88 | UTS2R (0.61) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5955941 | 0.88 | UTS2R (0.57) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5734191 | 0.88 | UTS2R (0.59) | LMNASMN1; SMN2UTS2RADRA2ADRD2 | |
| SCHEMBL5956049 | 0.87 | UTS2R (0.60) | LMNASMN1; SMN2UTS2RADRA2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-09-21 | — | — | US | claimed |
| EP-1631565-A1 | PIPERAZINE-ALKYL-UREIDO DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2006-03-08 | — | — | EP | claimed |
| WO-2004099179-A1 | PIPERAZINE-ALKYL-UREIDO DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-11-18 | — | — | WO | claimed |
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ADRA2C, UTS2R, ADRB2 | LMNA 1677/4885SMN1; SMN2 2314/4885UTS2R 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.