Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587281 | 0.86 | TGFBR1 (0.62) | ROCK2TGFBR1ROCK1CLK2BLK | |
| SCHEMBL3580880 | 0.82 | RET (0.64) | RETKDRROCK2TGFBR1ROCK1 | |
| SCHEMBL221437 | 0.80 | RET (0.66) | RETKDRROCK2TGFBR1EGFR | |
| SCHEMBL29677296 | 0.80 | RET (0.66) | RETKDRROCK2TGFBR1EGFR | |
| SCHEMBL3583259 | 0.80 | ROCK2 (0.64) | RETKDRROCK2TGFBR1ROCK1 | |
| SCHEMBL13154702 | 0.79 | RET (0.72) | RETKDRROCK2TGFBR1EGFR | |
| SCHEMBL13316009 | 0.78 | RET (0.66) | RETKDRROCK2TGFBR1EGFR | |
| SCHEMBL2454370 | 0.78 | RET (0.71) | RETKDRROCK2EGFRROCK1 | |
| SCHEMBL13154704 | 0.77 | RET (0.70) | RETKDRROCK2EGFRROCK1 | |
| SCHEMBL3588668 | 0.76 | RET (0.61) | RETKDRROCK2TGFBR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370553-B1 | RHO-KINASE INHIBITORS | BAYER AG (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1370553-B1 | RHO-KINASE INHIBITORS | BAYER AG (US) | 2006-05-10 | — | — | EP | disclosed |