SCHEMBL5736362

SCHEMBL5736362

COc1cccc([C]2CCCCC2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.50
CLK4 Q9HAZ1 1/20 0.50
GAA P10253 2/20 0.49
CYP1A1 P04798 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2E1 P05181 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C8 P10632 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2A6 P11509 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP4B1 P13584 1/20 0.48
CYP2B6 P20813 1/20 0.48
CYP3A5 P20815 1/20 0.48
CYP2A7 P20853 1/20 0.48
CYP3A7 P24462 1/20 0.48
CYP2F1 P24903 1/20 0.48
CYP2C18 P33260 1/20 0.48
CYP2C19 P33261 1/20 0.48
CYP2J2 P51589 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7844830 0.98 DYRK1A (0.52) DYRK1ACLK4GAACYP1A1CYP1A2
SCHEMBL1515073 0.94 GAA (0.54) DYRK1ACLK4GAACYP1A1CYP1A2
SCHEMBL1515133 0.90 DYRK1A (0.55) DYRK1ACLK4GAACYP1A1CYP1A2
SCHEMBL1257312 0.79 RAB9A (0.50) DYRK1ACLK4GAACYP1A1CYP1A2
SCHEMBL196765 0.79 CYP3A4 (0.73) DYRK1ACLK4GAACYP1A1CYP1A2
SCHEMBL29489425 0.79 CYP3A4 (0.73) DYRK1ACLK4GAACYP1A1CYP1A2
SCHEMBL17514729 0.77 ALDH1A1 (0.52) CYP1A1CYP1A2CYP2E1CYP3A4CYP2C8
Hydrogen Sulfide SCHEMBL28640169 0.77 CYP3A4 (0.70) DYRK1ACLK4GAACYP1A1CYP1A2
SCHEMBL29628977 0.77 CYP3A4 (0.77) DYRK1ACLK4GAACYP1A1CYP1A2
Ammonia Solution, Strong SCHEMBL27960505 0.77 CYP3A4 (0.70) DYRK1ACLK4GAACYP1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1734942-A1 SUBSTITUTED UREA AND CARBAMATE, PHENACYL-2-HYDROXY-3-DIAMINOALKANE, AND BENZAMIDE-2-HYDROXY-3-DIAMINOALKANE ASPARTYL-PROTEASE INHIBITORS ELAN PHARMACEUTICALS, INC. (US) 2006-12-27 EP disclosed
WO-2005087215-A1 SUBSTITUTED UREA AND CARBAMATE, PHENACYL-2-HYDROXY-3-DIAMINOALKANE, AND BENZAMIDE-2-HYDROXY-3-DIAMINOALKANE ASPARTYL-PROTEASE INHIBITORS ELAN PHARMACEUTICALS, INC. (US) 2005-09-22 WO disclosed
EP-1064262-A1 SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS Aventis Pharma Deutschland GmbH (DE) 2001-01-03 EP disclosed
WO-1999042444-A1 SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 1999-08-26 WO disclosed