Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5734155 | 0.94 | UTS2R (0.70) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5735499 | 0.93 | UTS2R (0.64) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5956386 | 0.91 | UTS2R (0.62) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5733642 | 0.91 | UTS2R (0.62) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5955939 | 0.90 | UTS2R (0.61) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5732929 | 0.90 | UTS2R (0.61) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5956406 | 0.90 | UTS2R (0.61) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5732916 | 0.88 | UTS2R (0.65) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL4862849 | 0.86 | UTS2R (0.60) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5733022 | 0.85 | UTS2R (0.70) | UTS2RADRA2ADRD2SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-09-21 | — | — | US | claimed |
| CN-1784395-A | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-07 | — | — | CN | claimed |
| EP-1631565-A1 | PIPERAZINE-ALKYL-UREIDO DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2006-03-08 | — | — | EP | claimed |
| WO-2004099179-A1 | PIPERAZINE-ALKYL-UREIDO DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-11-18 | — | — | WO | claimed |
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-09-21 | — | — | US | disclosed |
| CN-1784395-A | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ADRA2C, UTS2R, ADRB2 | UTS2R 2/4885ADRA2A 7/4885DRD2 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.