Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 8/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 8/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | ERN1 | O75460 | 3/20 | 0.49 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.49 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.49 |
| ▸ | TYR | P14679 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 3/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31081472 | 0.86 | TYR (0.55) | ERN1TRIM24TRIM33TYRAPP | |
| SCHEMBL31099574 | 0.86 | TYR (0.55) | ERN1TRIM24TRIM33TYRAPP | |
| SCHEMBL6640030 | 0.85 | ERN1 (0.66) | HSD17B1HSD17B2CYP3A4CYP2C9ERN1 | |
| SCHEMBL29398976 | 0.85 | ALOX5 (0.57) | ERN1TRIM24TRIM33TYRESR2 | |
| SCHEMBL2786991 | 0.85 | ALOX5 (0.57) | ERN1TRIM24TRIM33TYRESR2 | |
| SCHEMBL31568859 | 0.84 | ERN1 (0.55) | ERN1TRIM24TRIM33TYRAPP | |
| SCHEMBL15329732 | 0.82 | MCL1 (0.53) | HSD17B1HSD17B2CYP3A4CYP2C9ERN1 | |
| SCHEMBL5736244 | 0.82 | ALOX5 (0.62) | ERN1TRIM24TRIM33TYRESR2 | |
| SCHEMBL30008990 | 0.82 | TYR (0.52) | ERN1TRIM24TRIM33TYRAPP | |
| SCHEMBL15331501 | 0.80 | ERN1 (0.77) | ERN1TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244446-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-11-02 | — | — | EP | disclosed |
| US-6858630-B2 | Naphthimidazole derivatives and their use as thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-22 | — | — | US | disclosed |
| US-20030083361-A1 | Naphtho(1,2-d)imidazole derivatives; treating thrombocytopenia | SMITHKLINE BEECHAM CORPORATION | 2003-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083361-A1 | Naphtho(1,2-d)imidazole derivatives; treating thrombocytopenia | MPL, THPO, TPO | HSD17B1 4390/4885HSD17B2 4276/4885CYP3A4 3542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.