SCHEMBL5737277

SCHEMBL5737277

Nc1cc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)cc2)[nH]n1

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 0.56
ATM Q13315 1/20 0.52
F2 P00734 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6197875 0.83 F10 (0.60) F10ATM
Hydrochloric Acid SCHEMBL5737086 0.83 F10 (0.55) F10ATMF2
SCHEMBL5736178 0.83 F10 (0.64) F10ATM
SCHEMBL6728205 0.82 ATM (0.55) F10ATMF2
SCHEMBL5736610 0.82 F10 (0.56) F10ATMF2
Hydrochloric Acid SCHEMBL6197839 0.81 ATM (0.54) F10ATMF2
Hydrochloric Acid SCHEMBL6200589 0.81 F10 (0.54) F10ATMF2
SCHEMBL6152346 0.81 ALDH1A1 (0.59) F10ATMF2
SCHEMBL5193868 0.81 ATM (0.71) F10ATMF2
Hydrochloric Acid SCHEMBL6195200 0.81 F10 (0.55) F10ATMF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0986551-B1 SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA PHARMACEUTICAL (JP) 2006-08-02 EP disclosed
US-6359134-B1 ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-19 US disclosed