SCHEMBL573764

SCHEMBL573764

CCCCCc1c(O)cc(C)c(Cl)c1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.48
NPC1 O15118 1/20 0.48
HPGD P15428 1/20 0.48
MAPK1 P28482 1/20 0.48
RAB9A P51151 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
CYP19A1 P11511 1/20 0.47
MAPT P10636 2/20 0.47
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.47
ALOX5 P09917 6/20 0.43
TYR P14679 2/20 0.43
CYP3A4 P08684 2/20 0.43
MEN1 O00255 1/20 0.43
TP53 P04637 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
KMT2A Q03164 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
PTGS2 P35354 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31395450 1.00 HTT (0.48) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL17374025 0.89 ALDH1A1 (0.50) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL28299697 0.85 CYP19A1 (0.54) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL30640325 0.83 CYP19A1 (0.53) HTTNPC1HPGDMAPK1RAB9A
Formaldehyde SCHEMBL27643836 0.82 ALOX5 (0.44) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL11036424 0.81 ALDH1A1 (0.47) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL69778 0.80 MAPT (0.53) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL18371595 0.80 CYP19A1 (0.53) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL574465 0.80 ALDH1A1 (0.53) HTTNPC1HPGDMAPK1RAB9A
SCHEMBL22692794 0.79 CYP19A1 (0.49) HTTNPC1HPGDMAPK1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3528776-B1 REDUCED-ETHANOL MOUTH RINSE FORMULATIONS KENVUE BRANDS LLC (US) 2025-11-26 EP disclosed
US-12201987-B2 Pipette tip rack BIOTIX, INC. (US) 2025-01-21 US disclosed
US-11857653-B2 Method of providing an oral care benefit using a poorly-soluble calcium compound and fluoride JOHNSON & JOHNSON CONSUMER INC. (US) 2024-01-02 US disclosed
US-11648186-B2 Coated particles and their uses JOHNSON & JOHNSON CONSUMER INC. (US) 2023-05-16 US disclosed
US-11590490-B2 Pipette tips BIOTIX, INC. (US) 2023-02-28 US disclosed
US-20220331222-A1 Method of Providing Oral Care Benefits KENVUE BRANDS LLC 2022-10-20 US disclosed
US-20220226205-A1 Coated Particles and Their Uses KENVUE BRANDS LLC 2022-07-21 US disclosed
US-11351103-B2 Method of providing oral care benefits JOHNSON & JOHNSON CONSUMER INC. (US) 2022-06-07 US disclosed
US-11291613-B2 Coated particles and their uses JOHNSON & JOHNSON CONSUMER INC. (US) 2022-04-05 US disclosed
EP-3897511-A1 METHOD OF PROVIDING AN ORAL CARE BENEFIT USING A POORLY-SOLUBLE CALCIUM COMPOUND AND FLUORIDE Johnson & Johnson Consumer Inc. (US) 2021-10-27 EP disclosed
US-5776435-A DENTIFRICES COLGATE-PALMOLIVE COMPANY (US) 1998-07-07 US disclosed
US-5686064-A MIXTURE INCLUDES TETRAALKALI METAL POLYPHOSPHATE AND TRICLOSAN; DENTIFRICES COLGATE PALMOLIVE COMPANY (US) 1997-11-11 US disclosed
US-5681548-A CONTAINING AMPHOTERIC SURFACTANT AND MICROBIOCIDE COLGATE PALMOLIVE COMPANY (US) 1997-10-28 US disclosed
US-5575652-A Process for applying antibacterial oral composition to dental implant areas COLGATE PALMOLIVE COMPANY (US) 1996-11-19 US disclosed
US-5538715-A DENTIFRICES WITH ANTIPLAQUE AGENTS FOR MOUTHS WITH HUMECTANTS, SILICA POLISHES AND BACTERICIDES COLGATE PALMOLIVE COMPANY (US) 1996-07-23 US disclosed
US-5288480-A Antiplaque antibacterial oral composition COLGATE-PALMOLIVE CO. (US) 1994-02-22 US disclosed
US-5192530-A Solubilizer, enhancing agent to aid retention, and delivery enhancement COLGATE-PALMOLIVE COMPANY (US) 1993-03-09 US disclosed
US-5178851-A Dentifrices treatment with triclosan and carriers COLGATE-PALMOLIVE COMPANY (US) 1993-01-12 US disclosed
US-5080887-A Polyphosphate, bactericide COLGATE-PALMOLIVE COMPANY (US) 1992-01-14 US disclosed
US-4894220-A WATER AND ALCOHOL SOLVENTS, GLYCOL DERIVATIVES AND ESTERS SOLUTIONS COLGATE-PALMOLIVE COMPANY (US) 1990-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11291613-B2 Coated particles and their uses CD63, EPCAM, CD44 HTT 1520/4885NPC1 2820/4885HPGD 3992/4885
US-11648186-B2 Coated particles and their uses CD63, EPCAM, CD44 HTT 1520/4885NPC1 2820/4885HPGD 3992/4885
US-20220226205-A1 Coated Particles and Their Uses CD63, EPCAM, CD44 HTT 1520/4885NPC1 2820/4885HPGD 3992/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.