Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.44 |
| ▸ | HTR2A | P28223 | 13/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.44 |
| ▸ | DRD2 | P14416 | 11/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777922 | 0.84 | HTR1A (0.41) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6400727 | 0.83 | HTR1A (0.65) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL5750335 | 0.82 | HTR1A (0.39) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL5777920 | 0.80 | HTR1A (0.40) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6406964 | 0.77 | HTR2A (0.48) | HTR1AHTR2ADRD2HTR7 | |
| SCHEMBL6399699 | 0.74 | HTR1A (0.61) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6400489 | 0.73 | HTR1A (0.63) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6399709 | 0.72 | HTR1A (0.61) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6397588 | 0.69 | HTR1A (0.55) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6400115 | 0.69 | HTR1A (0.68) | HTR1AHTR2AKCNH2DRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697334-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005056540-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-23 | — | — | WO | disclosed |