Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.40 |
| ▸ | HTR2A | P28223 | 14/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.40 |
| ▸ | DRD2 | P14416 | 11/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402177 | 0.84 | HTR1A (0.57) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL5777922 | 0.83 | HTR1A (0.41) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6397693 | 0.80 | HTR1A (0.56) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL5738181 | 0.80 | HTR1A (0.44) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6401301 | 0.79 | HTR1A (0.56) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6399872 | 0.75 | HTR1A (0.55) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6399037 | 0.72 | HTR1A (0.68) | HTR1AHTR2AKCNH2DRD2 | |
| SCHEMBL6401307 | 0.67 | HTR1A (0.59) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL22049741 | 0.67 | HTR3A (0.51) | — | |
| SCHEMBL6398868 | 0.67 | HTR1A (0.67) | HTR1AHTR2AKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697334-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005056540-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-23 | — | — | WO | disclosed |