Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740220 | 0.89 | EGFR (0.48) | EGFRERBB2KDRMAPK14 | |
| SCHEMBL5741109 | 0.85 | EGFR (0.45) | EGFRERBB2 | |
| SCHEMBL5739083 | 0.85 | EGFR (0.59) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5512127 | 0.83 | EGFR (0.70) | EGFRERBB2KDRMAPK14MAP2K1 | |
| SCHEMBL5740547 | 0.83 | EGFR (0.50) | EGFRERBB2KDRMAPK14MAP2K1 | |
| SCHEMBL5739637 | 0.83 | EGFR (0.72) | EGFRERBB2MAPK14MAP2K1 | |
| SCHEMBL5739177 | 0.81 | EGFR (0.46) | EGFRERBB2KDRMAPK14MAP2K1 | |
| SCHEMBL5741061 | 0.81 | EGFR (0.46) | EGFRERBB2KDRMAPK14MAP2K1 | |
| SCHEMBL5740236 | 0.81 | EGFR (0.59) | EGFRERBB2KDRMAPK14MAP2K1 | |
| SCHEMBL5740085 | 0.80 | EGFR (0.62) | EGFRERBB2KDRMAPK14MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |