Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739083 | 0.90 | EGFR (0.59) | EGFRERBB2MAP2K1SMN1; SMN2MEN1 | |
| SCHEMBL5740236 | 0.90 | EGFR (0.59) | EGFRERBB2GAAMAP2K1MAPK14 | |
| SCHEMBL5742139 | 0.89 | EGFR (0.58) | EGFRERBB2 | |
| SCHEMBL5740085 | 0.86 | EGFR (0.62) | EGFRERBB2MAP2K1MAPK14 | |
| SCHEMBL4052269 | 0.84 | EGFR (1.00) | EGFRERBB2GAAMAP2K1SMN1; SMN2 | |
| SCHEMBL5739062 | 0.83 | EGFR (0.49) | EGFRERBB2MAP2K1MAPK14 | |
| SCHEMBL5740257 | 0.83 | EGFR (0.50) | EGFRERBB2MAP2K1MAPK14ALDH1A1 | |
| SCHEMBL5739239 | 0.83 | EGFR (0.50) | EGFRERBB2MAP2K1MAPK14ALDH1A1 | |
| SCHEMBL5740547 | 0.82 | EGFR (0.50) | EGFRERBB2MAP2K1SMN1; SMN2MAPK14 | |
| SCHEMBL5740220 | 0.82 | EGFR (0.48) | EGFRERBB2MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |