Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740257 | 1.00 | EGFR (0.50) | EGFRERBB2MAPK14KDM4EALDH1A1 | |
| SCHEMBL4374656 | 0.85 | EGFR (0.69) | EGFRERBB2MAPK14KDM4EALDH1A1 | |
| SCHEMBL4045650 | 0.85 | EGFR (0.69) | EGFRERBB2MAPK14KDM4EALDH1A1 | |
| SCHEMBL5740085 | 0.84 | EGFR (0.62) | EGFRERBB2MAPK14MAP2K1 | |
| SCHEMBL5739637 | 0.83 | EGFR (0.72) | EGFRERBB2MAPK14ALDH1A1LMNA | |
| SCHEMBL5739083 | 0.81 | EGFR (0.59) | EGFRERBB2KDM4EALDH1A1LMNA | |
| SCHEMBL5739459 | 0.80 | EGFR (0.74) | EGFRERBB2MAPK14MAP2K1 | |
| SCHEMBL5740274 | 0.78 | EGFR (0.56) | EGFRERBB2MAPK14MAP2K1 | |
| SCHEMBL5739062 | 0.77 | EGFR (0.49) | EGFRERBB2MAPK14MAP2K1 | |
| SCHEMBL5740547 | 0.77 | EGFR (0.50) | EGFRERBB2MAPK14KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |